BDBM5138 5-{[(5Z)-4-[(3-chloro-4-fluorophenyl)amino]-6-oxo-5H,6H,7H-pyrrolo[2,3-d]pyrimidin-5-ylidene]methyl}-N-[2-(diethylamino)ethyl]-4-methyl-1H-pyrrole-2-carboxamide::pyrrolo[2,3-d]pyrimidin-6-one deriv. 26p

SMILES: CCN(CC)CCNC(=O)c1cc(C)c(\C=C2/C(=O)Nc3ncnc(Nc4ccc(F)c(Cl)c4)c23)[nH]1

InChI Key: InChIKey=SXQLWNOERMLQGM-VBKFSLOCSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 5138   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5138 (5-{[(5Z)-4-[(3-chloro-4-fluorophenyl)amino]-6-oxo-...) Show SMILES CCN(CC)CCNC(=O)c1cc(C)c(\C=C2/C(=O)Nc3ncnc(Nc4ccc(F)c(Cl)c4)c23)[nH]1 Show InChI InChI=1S/C25H27ClFN7O2/c1-4-34(5-2)9-8-28-25(36)20-10-14(3)19(32-20)12-16-21-22(29-13-30-23(21)33-24(16)35)31-15-6-7-18(27)17(26)11-15/h6-7,10-13,32H,4-5,8-9H2,1-3H3,(H,28,36)(H2,29,30,31,33,35)/b16-12-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	7.5	22
SUGEN, Inc.					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM5138 (5-{[(5Z)-4-[(3-chloro-4-fluorophenyl)amino]-6-oxo-...) Show SMILES CCN(CC)CCNC(=O)c1cc(C)c(\C=C2/C(=O)Nc3ncnc(Nc4ccc(F)c(Cl)c4)c23)[nH]1 Show InChI InChI=1S/C25H27ClFN7O2/c1-4-34(5-2)9-8-28-25(36)20-10-14(3)19(32-20)12-16-21-22(29-13-30-23(21)33-24(16)35)31-15-6-7-18(27)17(26)11-15/h6-7,10-13,32H,4-5,8-9H2,1-3H3,(H,28,36)(H2,29,30,31,33,35)/b16-12-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc.					Assay Description IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM5138 (5-{[(5Z)-4-[(3-chloro-4-fluorophenyl)amino]-6-oxo-...) Show SMILES CCN(CC)CCNC(=O)c1cc(C)c(\C=C2/C(=O)Nc3ncnc(Nc4ccc(F)c(Cl)c4)c23)[nH]1 Show InChI InChI=1S/C25H27ClFN7O2/c1-4-34(5-2)9-8-28-25(36)20-10-14(3)19(32-20)12-16-21-22(29-13-30-23(21)33-24(16)35)31-15-6-7-18(27)17(26)11-15/h6-7,10-13,32H,4-5,8-9H2,1-3H3,(H,28,36)(H2,29,30,31,33,35)/b16-12-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc.					Assay Description IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair