BDBM5144 (5Z)-4-[(1-benzyl-1H-indol-5-yl)amino]-5-{[3-methyl-5-(morpholin-4-ylcarbonyl)-1H-pyrrol-2-yl]methylidene}-5H,6H,7H-pyrrolo[2,3-d]pyrimidin-6-one::pyrrolo[2,3-d]pyrimidin-6-one deriv. 28b

SMILES: Cc1cc([nH]c1\C=C1/C(=O)Nc2ncnc(Nc3ccc4n(Cc5ccccc5)ccc4c3)c12)C(=O)N1CCOCC1

InChI Key: InChIKey=CBRVEUABHHKTIL-ULJHMMPZSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 5144   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5144 ((5Z)-4-[(1-benzyl-1H-indol-5-yl)amino]-5-{[3-methy...) Show SMILES Cc1cc([nH]c1\C=C1/C(=O)Nc2ncnc(Nc3ccc4n(Cc5ccccc5)ccc4c3)c12)C(=O)N1CCOCC1 Show InChI InChI=1S/C32H29N7O3/c1-20-15-26(32(41)38-11-13-42-14-12-38)36-25(20)17-24-28-29(33-19-34-30(28)37-31(24)40)35-23-7-8-27-22(16-23)9-10-39(27)18-21-5-3-2-4-6-21/h2-10,15-17,19,36H,11-14,18H2,1H3,(H2,33,34,35,37,40)/b24-17-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.05E+3	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc.					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM5144 ((5Z)-4-[(1-benzyl-1H-indol-5-yl)amino]-5-{[3-methy...) Show SMILES Cc1cc([nH]c1\C=C1/C(=O)Nc2ncnc(Nc3ccc4n(Cc5ccccc5)ccc4c3)c12)C(=O)N1CCOCC1 Show InChI InChI=1S/C32H29N7O3/c1-20-15-26(32(41)38-11-13-42-14-12-38)36-25(20)17-24-28-29(33-19-34-30(28)37-31(24)40)35-23-7-8-27-22(16-23)9-10-39(27)18-21-5-3-2-4-6-21/h2-10,15-17,19,36H,11-14,18H2,1H3,(H2,33,34,35,37,40)/b24-17-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc.					Assay Description IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM5144 ((5Z)-4-[(1-benzyl-1H-indol-5-yl)amino]-5-{[3-methy...) Show SMILES Cc1cc([nH]c1\C=C1/C(=O)Nc2ncnc(Nc3ccc4n(Cc5ccccc5)ccc4c3)c12)C(=O)N1CCOCC1 Show InChI InChI=1S/C32H29N7O3/c1-20-15-26(32(41)38-11-13-42-14-12-38)36-25(20)17-24-28-29(33-19-34-30(28)37-31(24)40)35-23-7-8-27-22(16-23)9-10-39(27)18-21-5-3-2-4-6-21/h2-10,15-17,19,36H,11-14,18H2,1H3,(H2,33,34,35,37,40)/b24-17-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.5	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc.					Assay Description IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair