BDBM5152 (2E)-2-cyano-N-{4-[(2E)-2-cyano-3-(3,4,5-trihydroxyphenyl)prop-2-enamido]butyl}-3-(3,4,5-trihydroxyphenyl)prop-2-enamide::CHEMBL358746::Dimeric Tyrphostin 5
SMILES: Oc1cc(\C=C(/C#N)C(=O)NCCCCNC(=O)C(=C\c2cc(O)c(O)c(O)c2)\C#N)cc(O)c1O
InChI Key: InChIKey=ZJGWOFFIHTYMCZ-IAGONARPSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dynamin-1 (Homo sapiens (Human)) | BDBM5152 ((2E)-2-cyano-N-{4-[(2E)-2-cyano-3-(3,4,5-trihydrox...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Newcastle Curated by ChEMBL | Assay Description Inhibitory activity against dynamin1 GTPase expressed in sheep brain | J Med Chem 48: 7781-8 (2005) Article DOI: 10.1021/jm040208l BindingDB Entry DOI: 10.7270/Q2BC3Z41 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM5152 ((2E)-2-cyano-N-{4-[(2E)-2-cyano-3-(3,4,5-trihydrox...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 600 | n/a | n/a | n/a | n/a | 7.6 | 22 |
Hebrew University of Jerusalem | Assay Description The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate. | J Med Chem 39: 4905-11 (1996) Article DOI: 10.1021/jm960225d BindingDB Entry DOI: 10.7270/Q2V69GSZ | |||||||||||
More data for this Ligand-Target Pair |