BindingDB PrimarySearch

null

SMILES: COC[C@@H](C)Nc1n[nH]c2nccc(Oc3ccc(NC(=O)c4cn(C5CCC5)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c12

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 517091
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM517091 ((R)-1-cyclobutyl-N-(3- fluoro-4-((3-((1- methoxypr...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen� Eu Kinase Binding technol...				Citation and Details BindingDB Entry DOI: 10.7270/Q2BZ6962
TBA					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM517091 ((R)-1-cyclobutyl-N-(3- fluoro-4-((3-((1- methoxypr...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen� Eu Kinase Binding technol...				Citation and Details BindingDB Entry DOI: 10.7270/Q2BZ6962
TBA					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM517091 ((R)-1-cyclobutyl-N-(3- fluoro-4-((3-((1- methoxypr...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen� Eu Kinase Binding technol...				Citation and Details BindingDB Entry DOI: 10.7270/Q2BZ6962
TBA					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM517091 ((R)-1-cyclobutyl-N-(3- fluoro-4-((3-((1- methoxypr...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen� Eu Kinase Binding technol...				Citation and Details BindingDB Entry DOI: 10.7270/Q2BZ6962
TBA					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor [1-13,15-1390] (Homo sapiens (Human))	BDBM517091 ((R)-1-cyclobutyl-N-(3- fluoro-4-((3-((1- methoxypr...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen� Eu Kinase Binding technol...				Citation and Details BindingDB Entry DOI: 10.7270/Q2BZ6962
TBA					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor [Y1230S] (Homo sapiens (Human))	BDBM517091 ((R)-1-cyclobutyl-N-(3- fluoro-4-((3-((1- methoxypr...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen� Eu Kinase Binding technol...				Citation and Details BindingDB Entry DOI: 10.7270/Q2BZ6962
TBA					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor [D1228N] (Homo sapiens (Human))	BDBM517091 ((R)-1-cyclobutyl-N-(3- fluoro-4-((3-((1- methoxypr...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen� Eu Kinase Binding technol...				Citation and Details BindingDB Entry DOI: 10.7270/Q2BZ6962
TBA					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor [F1200I] (Homo sapiens (Human))	BDBM517091 ((R)-1-cyclobutyl-N-(3- fluoro-4-((3-((1- methoxypr...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen� Eu Kinase Binding technol...				Citation and Details BindingDB Entry DOI: 10.7270/Q2BZ6962
TBA					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor [L1195V] (Homo sapiens (Human))	BDBM517091 ((R)-1-cyclobutyl-N-(3- fluoro-4-((3-((1- methoxypr...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	22.4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen� Eu Kinase Binding technol...				Citation and Details BindingDB Entry DOI: 10.7270/Q2BZ6962
TBA					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor [Y1230C] (Homo sapiens (Human))	BDBM517091 ((R)-1-cyclobutyl-N-(3- fluoro-4-((3-((1- methoxypr...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen� Eu Kinase Binding technol...				Citation and Details BindingDB Entry DOI: 10.7270/Q2BZ6962
TBA					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor [Y1230H] (Homo sapiens (Human))	BDBM517091 ((R)-1-cyclobutyl-N-(3- fluoro-4-((3-((1- methoxypr...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen� Eu Kinase Binding technol...				Citation and Details BindingDB Entry DOI: 10.7270/Q2BZ6962
TBA					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor [D1228H] (Homo sapiens (Human))	BDBM517091 ((R)-1-cyclobutyl-N-(3- fluoro-4-((3-((1- methoxypr...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen� Eu Kinase Binding technol...				Citation and Details BindingDB Entry DOI: 10.7270/Q2BZ6962
TBA					More data for this Ligand-Target Pair