null

SMILES: CCNC(=O)c1cc(Nc2nc(cc3ncn(C(C)C)c23)-c2cnc3c(c2)N(C(=O)C3(C)C)C2(CC(C)C2)N2CCC3CC3C2)c(F)c(F)c1Cl

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 529845   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM529845 (US11203591, Example 251) Show SMILES CCNC(=O)c1cc(Nc2nc(cc3ncn(C(C)C)c23)-c2cnc3c(c2)N(C(=O)C3(C)C)C2(CC(C)C2)N2CCC3CC3C2)c(F)c(F)c1Cl |(11.87,6.69,;10.53,5.92,;9.2,6.69,;7.87,5.92,;7.87,4.38,;6.53,6.69,;5.2,5.92,;3.86,6.69,;2.53,5.92,;2.53,4.38,;3.86,3.61,;3.86,2.07,;2.53,1.3,;1.2,2.07,;-.27,1.6,;-1.17,2.84,;-.27,4.09,;-.74,5.55,;-2.25,5.87,;.29,6.7,;1.2,3.61,;5.2,1.3,;6.53,2.07,;7.87,1.3,;7.87,-.24,;6.53,-1.01,;5.2,-.24,;6.85,-2.51,;8.38,-2.67,;9.15,-4.01,;9.01,-1.27,;10.48,-1.73,;10.16,-.25,;5.82,-3.66,;6.97,-4.69,;5.94,-5.83,;6.02,-7.37,;4.79,-4.8,;4.68,-2.63,;5,-1.12,;3.85,-.09,;2.39,-.57,;.92,-1.04,;2.07,-2.07,;3.21,-3.1,;3.86,8.23,;2.53,9,;5.2,9,;5.2,10.54,;6.53,8.23,;7.87,9,)| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	0.0400	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q2833W6Q
					More data for this Ligand-Target Pair