null
SMILES: N[C@H]1CCN(C[C@H]1F)c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1
InChI Key:
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Metallo-beta-lactamase type 2 (Klebsiella pneumoniae) | BDBM531067 (4-((3R,4S)-4-amino-3- fluoropiperidin-1-yl)-N1-((R...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.69 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2FN19BS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metallo-beta-lactamase VIM-2 (Pseudomonas aeruginosa (g-Proteobacteria)) | BDBM531067 (4-((3R,4S)-4-amino-3- fluoropiperidin-1-yl)-N1-((R...) | PDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.27 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2FN19BS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
VIM-1 metallo-beta-lactamase (Klebsiella pneumoniae) | BDBM531067 (4-((3R,4S)-4-amino-3- fluoropiperidin-1-yl)-N1-((R...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.180 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2FN19BS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase (Pseudomonas aeruginosa) | BDBM531067 (4-((3R,4S)-4-amino-3- fluoropiperidin-1-yl)-N1-((R...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 6.11 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2FN19BS | |||||||||||
More data for this Ligand-Target Pair |