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SMILES: CN1CCN(CC1)C(=O)c1ccc2[nH]c(cc2c1)-c1cc2ccccc2[nH]c1=O

InChI Key: InChIKey=FINHYBFECTZECE-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 5333   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM5333
PNG
(3-{5-[(4-methylpiperazin-1-yl)carbonyl]-1H-indol-2...)
Show SMILES CN1CCN(CC1)C(=O)c1ccc2[nH]c(cc2c1)-c1cc2ccccc2[nH]c1=O
Show InChI InChI=1S/C23H22N4O2/c1-26-8-10-27(11-9-26)23(29)16-6-7-20-17(12-16)14-21(24-20)18-13-15-4-2-3-5-19(15)25-22(18)28/h2-7,12-14,24H,8-11H2,1H3,(H,25,28)
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Article
PubMed
n/an/a 5n/an/an/an/a7.422



Merck Research Laboratories



Assay Description
Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...

Bioorg Med Chem Lett 14: 351-5 (2004)


Article DOI: 10.1016/j.bmcl.2003.11.007
BindingDB Entry DOI: 10.7270/Q298856Z
More data for this
Ligand-Target Pair