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SMILES: CC(=O)c1c(C)c2cnc(Nc3ccc(cn3)N3CCCC4(CCNCC4)C3)nc2n(C2CCCC2)c1=O

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 533738   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-A2 [177-432]/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM533738 (US11225492, Compound 6) Show SMILES CC(=O)c1c(C)c2cnc(Nc3ccc(cn3)N3CCCC4(CCNCC4)C3)nc2n(C2CCCC2)c1=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In vitro enzymatic activity of the CDK isoforms CDK2/CycA2, CDK4/CycD3 and CDK6/cycD3 were measured using Mobility Shift Assay that monitors phosphor...				Citation and Details BindingDB Entry DOI: 10.7270/Q27S7RZ1
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 (Homo sapiens (Human))	BDBM533738 (US11225492, Compound 6) Show SMILES CC(=O)c1c(C)c2cnc(Nc3ccc(cn3)N3CCCC4(CCNCC4)C3)nc2n(C2CCCC2)c1=O Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In vitro enzymatic activity of the CDK isoforms CDK2/CycA2, CDK4/CycD3 and CDK6/cycD3 were measured using Mobility Shift Assay that monitors phosphor...				Citation and Details BindingDB Entry DOI: 10.7270/Q27S7RZ1
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4/G1/S-specific cyclin-D3 (Homo sapiens (Human))	BDBM533738 (US11225492, Compound 6) Show SMILES CC(=O)c1c(C)c2cnc(Nc3ccc(cn3)N3CCCC4(CCNCC4)C3)nc2n(C2CCCC2)c1=O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<25	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In vitro enzymatic activity of the CDK isoforms CDK2/CycA2, CDK4/CycD3 and CDK6/cycD3 were measured using Mobility Shift Assay that monitors phosphor...				Citation and Details BindingDB Entry DOI: 10.7270/Q27S7RZ1
					More data for this Ligand-Target Pair