BDBM5369 5-(1-phenyl-1H-1,3-benzodiazol-5-yl)-1-[3-(piperidin-1-yl)propyl]-1,2-dihydropyridin-2-one::benzimidazole deriv. 8

SMILES: O=c1ccc(cn1CCCN1CCCCC1)-c1ccc2n(cnc2c1)-c1ccccc1

InChI Key: InChIKey=NDYCHXYIBHPXJP-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 5369   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5369 (5-(1-phenyl-1H-1,3-benzodiazol-5-yl)-1-[3-(piperid...) Show SMILES O=c1ccc(cn1CCCN1CCCCC1)-c1ccc2n(cnc2c1)-c1ccccc1 Show InChI InChI=1S/C26H28N4O/c31-26-13-11-22(19-29(26)17-7-16-28-14-5-2-6-15-28)21-10-12-25-24(18-21)27-20-30(25)23-8-3-1-4-9-23/h1,3-4,8-13,18-20H,2,5-7,14-17H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	37	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 13: 2485-8 (2003) Article DOI: 10.1016/s0960-894x(03)00485-2 BindingDB Entry DOI: 10.7270/Q21R6NQ2
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