BDBM5386 2,4-Disubstituted Pyrimidine 2j::N-(3,5-dichlorophenyl)-4-(2-phenyl-1H-imidazol-1-yl)pyrimidin-2-amine

SMILES: Clc1cc(Cl)cc(Nc2nccc(n2)-n2ccnc2-c2ccccc2)c1

InChI Key: InChIKey=PRMOKNGXXJPBMD-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 5386   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5386 (2,4-Disubstituted Pyrimidine 2j | N-(3,5-dichlorop...) Show SMILES Clc1cc(Cl)cc(Nc2nccc(n2)-n2ccnc2-c2ccccc2)c1 Show InChI InChI=1S/C19H13Cl2N5/c20-14-10-15(21)12-16(11-14)24-19-23-7-6-17(25-19)26-9-8-22-18(26)13-4-2-1-3-5-13/h1-12H,(H,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	26	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 13: 1673-7 (2003) Article DOI: 10.1016/s0960-894x(03)00244-0 BindingDB Entry DOI: 10.7270/Q2X0657G
					More data for this Ligand-Target Pair