BDBM5400 2,4-Disubstituted Pyrimidine 5b::N-(3,5-dimethylphenyl)-4-[2-(pyridin-3-yl)-1H-imidazol-1-yl]pyrimidin-2-amine

SMILES: Cc1cc(C)cc(Nc2nccc(n2)-n2ccnc2-c2cccnc2)c1

InChI Key: InChIKey=ZQFFEUAQGFFMDA-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 5400   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5400 (2,4-Disubstituted Pyrimidine 5b | N-(3,5-dimethylp...) Show SMILES Cc1cc(C)cc(Nc2nccc(n2)-n2ccnc2-c2cccnc2)c1 Show InChI InChI=1S/C20H18N6/c1-14-10-15(2)12-17(11-14)24-20-23-7-5-18(25-20)26-9-8-22-19(26)16-4-3-6-21-13-16/h3-13H,1-2H3,(H,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.39E+3	n/a	n/a	n/a	n/a	n/a	n/a
Rheinische Friedrich-Wilhelms-Universit£t Curated by ChEMBL					Assay Description Antagonist activity at VEGFR2				J Med Chem 55: 2932-42 (2012) Article DOI: 10.1021/jm201706b BindingDB Entry DOI: 10.7270/Q2RJ4KGS
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5400 (2,4-Disubstituted Pyrimidine 5b | N-(3,5-dimethylp...) Show SMILES Cc1cc(C)cc(Nc2nccc(n2)-n2ccnc2-c2cccnc2)c1 Show InChI InChI=1S/C20H18N6/c1-14-10-15(2)12-17(11-14)24-20-23-7-5-18(25-20)26-9-8-22-19(26)16-4-3-6-21-13-16/h3-13H,1-2H3,(H,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.39E+3	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 12: 3537-41 (2002) Article DOI: 10.1016/s0960-894x(02)00827-2 BindingDB Entry DOI: 10.7270/Q2S75DHR
					More data for this Ligand-Target Pair