BindingDB PrimarySearch

null

SMILES: CN1CCN(CC1)c1ccc(Nc2ncc3ccn(-c4ccc(F)c(NS(=O)(=O)C(C)(C)C)c4)c3n2)cc1

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 543629
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Bromodomain-containing protein 4 [75-147] (Homo sapiens (Human))	BDBM543629 (US11279703, TABLE 6.218 \| US11279703, TABLE 6.263) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	128	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description 1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2T43X8B
TBA					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM543629 (US11279703, TABLE 6.218 \| US11279703, TABLE 6.263) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description 1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2T43X8B
TBA					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [342-460] (Homo sapiens (Human))	BDBM543629 (US11279703, TABLE 6.218 \| US11279703, TABLE 6.263) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	67.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description 1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2T43X8B
TBA					More data for this Ligand-Target Pair
Bromodomain-containing protein 2 [91-163] (Homo sapiens (Human))	BDBM543629 (US11279703, TABLE 6.218 \| US11279703, TABLE 6.263) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	490	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description 1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2T43X8B
TBA					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM543629 (US11279703, TABLE 6.218 \| US11279703, TABLE 6.263) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	188	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description 1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2T43X8B
TBA					More data for this Ligand-Target Pair
Bromodomain testis-specific protein [22-138] (Homo sapiens (Human))	BDBM543629 (US11279703, TABLE 6.218 \| US11279703, TABLE 6.263) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	182	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description 1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2T43X8B
TBA					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM543629 (US11279703, TABLE 6.218 \| US11279703, TABLE 6.263) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	972	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description 1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2T43X8B
TBA					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM543629 (US11279703, TABLE 6.218 \| US11279703, TABLE 6.263) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	105	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description 1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2T43X8B
TBA					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [75-147] (Homo sapiens (Human))	BDBM543629 (US11279703, TABLE 6.218 \| US11279703, TABLE 6.263) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	228	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description 1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2T43X8B
TBA					More data for this Ligand-Target Pair
Bromodomain-containing protein 3 [51-123] (Homo sapiens (Human))	BDBM543629 (US11279703, TABLE 6.218 \| US11279703, TABLE 6.263) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	109	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description 1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2T43X8B
TBA					More data for this Ligand-Target Pair