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SMILES: COc1ccncc1-c1cc2n(ncc2c(C)n1)-c1cc2n(C)c(nc2c(n1)N1C[C@H]2C[C@@H]1CO2)N1CCNCC1

InChI Key:

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 547814   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S]


(Homo sapiens (Human))		BDBM547814
PNG
(WO2022090481, Example I-029)
Show SMILES COc1ccncc1-c1cc2n(ncc2c(C)n1)-c1cc2n(C)c(nc2c(n1)N1C[C@H]2C[C@@H]1CO2)N1CCNCC1 |r|
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
WIPO WO2022090481
n/an/a 0.900n/an/an/an/an/an/a


TBA

Assay Description
 Ba/F3 cells were ordered from DSMZ (ACC300, Lot17) and grown in RPMI-1640 (ATCC 30-2001) + 10 % FCS + 10 ng/ml IL-3 at 37 °C in 5 % CO2 atmosphere. ...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2765JH3
More data for this
Ligand-Target Pair