BindingDB PrimarySearch_ki

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null

SMILES: [#6]\[#6](-[#6])=[#6]/[#6]-[#6]-[#6]-[#7]-c1nc(-[#7]-c2cnn(c2)C([#6])([#6])[#6])ncc1-[#6](-[#7])=O

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 555569
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM555569 (US11344549, Example 245) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	40.8	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description JAK1 (the final concentration was 10 nM); ATP (the final concentration was 10 μM); ULight-labeled JAK-1 (Tyr1023) Peptide (the final concentrati...				Citation and Details BindingDB Entry DOI: 10.7270/Q2M048NJ
TBA					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM555569 (US11344549, Example 245) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	201	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description TYK2 (the final concentration was 8 nM); ATP (the final concentration was 20 μM); ULight-labeled JAK-1 (Tyr1023) Peptide (the final concentratio...				Citation and Details BindingDB Entry DOI: 10.7270/Q2M048NJ
TBA					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM555569 (US11344549, Example 245) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description JAK3 (the final concentration was 0.36 nM); ATP (the final concentration was 10 μM); ULight-labeled JAK-1 (Tyr1023) Peptide (the final concentra...				Citation and Details BindingDB Entry DOI: 10.7270/Q2M048NJ
TBA					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM555569 (US11344549, Example 245) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	16.9	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description JAK2 (the final concentration was 0.25 nM); ATP (the final concentration was 5 μM); ULight-labeled JAK-1 (Tyr1023) Peptide (the final concentrat...				Citation and Details BindingDB Entry DOI: 10.7270/Q2M048NJ
TBA					More data for this Ligand-Target Pair