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SMILES: OC(=O)c1ccc(cc1)-c1n[nH]c2cc(ccc12)C(F)(F)F

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 558875   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dual specificity mitogen-activated protein kinase kinase 4 (Homo sapiens (Human))	BDBM558875 (US11370770, Compound 6z) Show SMILES OC(=O)c1ccc(cc1)-c1n[nH]c2cc(ccc12)C(F)(F)F Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	720	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...				Citation and Details BindingDB Entry DOI: 10.7270/Q2HX1GWD
					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 4 (Homo sapiens (Human))	BDBM558875 (US11370770, Compound 6z) Show SMILES OC(=O)c1ccc(cc1)-c1n[nH]c2cc(ccc12)C(F)(F)F Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	360	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...				Citation and Details BindingDB Entry DOI: 10.7270/Q2HX1GWD
					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 4 (Homo sapiens (Human))	BDBM558875 (US11370770, Compound 6z) Show SMILES OC(=O)c1ccc(cc1)-c1n[nH]c2cc(ccc12)C(F)(F)F Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...				Citation and Details BindingDB Entry DOI: 10.7270/Q2HX1GWD
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM558875 (US11370770, Compound 6z) Show SMILES OC(=O)c1ccc(cc1)-c1n[nH]c2cc(ccc12)C(F)(F)F Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...				Citation and Details BindingDB Entry DOI: 10.7270/Q2HX1GWD
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 7 (Homo sapiens (Human))	BDBM558875 (US11370770, Compound 6z) Show SMILES OC(=O)c1ccc(cc1)-c1n[nH]c2cc(ccc12)C(F)(F)F Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...				Citation and Details BindingDB Entry DOI: 10.7270/Q2HX1GWD
					More data for this Ligand-Target Pair
MAP kinase-activated protein kinase 3 (Homo sapiens (Human))	BDBM558875 (US11370770, Compound 6z) Show SMILES OC(=O)c1ccc(cc1)-c1n[nH]c2cc(ccc12)C(F)(F)F Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>2.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...				Citation and Details BindingDB Entry DOI: 10.7270/Q2HX1GWD
					More data for this Ligand-Target Pair
MAP kinase-activated protein kinase 5 (Homo sapiens (Human))	BDBM558875 (US11370770, Compound 6z) Show SMILES OC(=O)c1ccc(cc1)-c1n[nH]c2cc(ccc12)C(F)(F)F Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	350	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...				Citation and Details BindingDB Entry DOI: 10.7270/Q2HX1GWD
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 6 (Homo sapiens (Human))	BDBM558875 (US11370770, Compound 6z) Show SMILES OC(=O)c1ccc(cc1)-c1n[nH]c2cc(ccc12)C(F)(F)F Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...				Citation and Details BindingDB Entry DOI: 10.7270/Q2HX1GWD
					More data for this Ligand-Target Pair
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM558875 (US11370770, Compound 6z) Show SMILES OC(=O)c1ccc(cc1)-c1n[nH]c2cc(ccc12)C(F)(F)F Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>2.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...				Citation and Details BindingDB Entry DOI: 10.7270/Q2HX1GWD
					More data for this Ligand-Target Pair