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null

SMILES: CN1CCC[C@H]1COc1nc(N2CC3CCC(C2)N3)c2cnc(c(C)c2n1)-c1cc(O)cc2ccccc12

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 573344
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
GTPase KRas [G12D] (Homo sapiens (Human))	BDBM573344 (US11453683, Example 190 \| US20230279025, Example 1...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	n/a	76.1	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q2QR5281
TBA					More data for this Ligand-Target Pair
GTPase KRas [G12D] (Homo sapiens (Human))	BDBM573344 (US11453683, Example 190 \| US20230279025, Example 1...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	64.1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q2QR5281
TBA					More data for this Ligand-Target Pair
GTPase KRas [G12D] (Homo sapiens (Human))	BDBM573344 (US11453683, Example 190 \| US20230279025, Example 1...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.63E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Table 2: The ability of a compound to bind to KRAS G12D was measured using a TR-FRET displacement assay. Biotinylated GDP-loaded recombinant human KR...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PR807K
TBA					More data for this Ligand-Target Pair
GTPase KRas [G12D] (Homo sapiens (Human))	BDBM573344 (US11453683, Example 190 \| US20230279025, Example 1...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	64.1	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Table 2: The ability of a compound to bind to KRAS G12D was measured using a TR-FRET displacement assay. Biotinylated GDP-loaded recombinant human KR...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PR807K
TBA					More data for this Ligand-Target Pair
GTPase KRas [G12D] (Homo sapiens (Human))	BDBM573344 (US11453683, Example 190 \| US20230279025, Example 1...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	76.1	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Table 1: Briefly, 1 L of 1.05� HBS-Mg buffer (262.5 mM Bioultra Hepes, pH 7.5, 157.5 mM NaCl, 105 mM MgCl2, 0.525 mM TCEP, 0.0305% Brij-35) was prepa...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PR807K
TBA					More data for this Ligand-Target Pair