null

SMILES: CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)C2CCC(CC2)NC2(COC2)C(F)(F)F)c2ccccc12

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 575006   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM575006 (US11459315, Example 130) Show SMILES CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)C2CCC(CC2)NC2(COC2)C(F)(F)F)c2ccccc12 |r,wD:18.19,(8.14,-24.02,;6.64,-24.34,;6.16,-25.81,;4.65,-26.13,;4.18,-27.59,;2.67,-27.91,;5.21,-28.74,;6.71,-28.42,;7.74,-29.56,;7.19,-26.95,;8.7,-26.63,;9.17,-25.17,;10.68,-24.85,;11.71,-25.99,;11.15,-23.38,;10.25,-22.14,;8.71,-22.14,;11.15,-20.89,;10.68,-19.43,;9.17,-19.11,;11.71,-18.28,;11.23,-16.82,;12.26,-15.67,;13.77,-15.99,;14.25,-17.46,;13.22,-18.6,;14.8,-14.85,;16.31,-15.17,;17.81,-15.49,;17.49,-17,;15.99,-16.68,;16.63,-13.66,;16.95,-12.16,;18.13,-13.98,;15.12,-13.34,;12.62,-21.37,;13.95,-20.6,;15.29,-21.37,;15.29,-22.91,;13.95,-23.68,;12.62,-22.91,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compound potencies were assessed through incorporation of 3H-SAM into a biotinylated H3 peptide. Specifically, 30 pM PRC2 containing wt EZH2 (pentame...				Citation and Details BindingDB Entry DOI: 10.7270/Q20Z76H4
					More data for this Ligand-Target Pair