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Target
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null
SMILES:
CC(C)n1nc(-c2noc(C3CC3)c2-c2ccccn2)c2c(N)ncc(Cl)c12
InChI Key:
Find this compound or compounds like it in BindingDB or PDB:
Substructure
Similarity at least:
must be >=0.5
Exact match
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found
5
hits for monomerid = 576988
Target/Host
(Institution)
Ligand
Target/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
k
off
s
-1
k
on
M
-1
s
-1
pH
Temp
°C
Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human))
BDBM576988
(US11472802, Example 8)
Show SMILES
CC(C)n1nc(-c2noc(C3CC3)c2-c2ccccn2)c2c(N)ncc(Cl)c12
Show InChI
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
PC cid
PC sid
UniChem
US Patent
n/a
n/a
0.0170
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
The potency of compounds inhibiting several different RET kinase forms (Wild Type, V804M, M918T, G810R, & G810S) were determined using CisBio's H...
Citation and Details
BindingDB Entry DOI:
10.7270/Q22N55HG
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [V804M]
(Homo sapiens (Human))
BDBM576988
(US11472802, Example 8)
Show SMILES
CC(C)n1nc(-c2noc(C3CC3)c2-c2ccccn2)c2c(N)ncc(Cl)c12
Show InChI
PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
PC cid
PC sid
UniChem
US Patent
n/a
n/a
0.0170
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Citation and Details
BindingDB Entry DOI:
10.7270/Q22N55HG
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [G810S]
(Homo sapiens (Human))
BDBM576988
(US11472802, Example 8)
Show SMILES
CC(C)n1nc(-c2noc(C3CC3)c2-c2ccccn2)c2c(N)ncc(Cl)c12
Show InChI
PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
PC cid
PC sid
UniChem
US Patent
n/a
n/a
0
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Citation and Details
BindingDB Entry DOI:
10.7270/Q22N55HG
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [G810R]
(Homo sapiens (Human))
BDBM576988
(US11472802, Example 8)
Show SMILES
CC(C)n1nc(-c2noc(C3CC3)c2-c2ccccn2)c2c(N)ncc(Cl)c12
Show InChI
PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
PC cid
PC sid
UniChem
US Patent
n/a
n/a
0.100
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Citation and Details
BindingDB Entry DOI:
10.7270/Q22N55HG
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [M918T]
(Homo sapiens (Human))
BDBM576988
(US11472802, Example 8)
Show SMILES
CC(C)n1nc(-c2noc(C3CC3)c2-c2ccccn2)c2c(N)ncc(Cl)c12
Show InChI
PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
PC cid
PC sid
UniChem
US Patent
n/a
n/a
0.0170
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Citation and Details
BindingDB Entry DOI:
10.7270/Q22N55HG
More data for this
Ligand-Target Pair
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