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SMILES: C[C@@H]1CN(Cc2cc(nc(n2)C2CC2)C(=O)Nc2cccc(c2)[C@@]2(Cc3nncn3C)C[C@@H](C2)C#N)CCC1(F)F

InChI Key:

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 585842   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]


(Homo sapiens (Human))		BDBM585842
PNG
(US11530229, Compound 57)
Show SMILES C[C@@H]1CN(Cc2cc(nc(n2)C2CC2)C(=O)Nc2cccc(c2)[C@@]2(Cc3nncn3C)C[C@@H](C2)C#N)CCC1(F)F |r,wU:32.38,wD:23.25,1.0,(-8.97,4.14,;-8.2,2.81,;-6.66,2.81,;-5.89,1.47,;-4.35,1.47,;-3.62,.14,;-2.08,.14,;-1.31,-1.19,;-2.08,-2.53,;-3.62,-2.53,;-4.39,-1.19,;-4.39,-3.86,;-5.72,-4.63,;-4.39,-5.4,;.23,-1.19,;1,.14,;1,-2.53,;2.54,-2.53,;3.31,-3.86,;4.85,-3.86,;5.62,-2.53,;4.85,-1.19,;3.31,-1.19,;5.62,.14,;6.39,-1.19,;7.93,-1.19,;8.84,.05,;10.3,-.42,;10.3,-1.96,;8.84,-2.44,;8.36,-3.9,;6.71,1.23,;5.62,2.32,;4.53,1.23,;5.62,3.86,;5.62,5.4,;-6.66,.14,;-8.2,.14,;-8.97,1.47,;-10.06,.38,;-10.3,2.24,)|
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<1n/an/an/an/an/an/a


TBA

Assay Description
The ability of candidate compounds to displace a known inhibitor and thereby inhibit Cbl-b activity was measured by monitoring the interaction of Cbl...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2280CGT
More data for this
Ligand-Target Pair