BDBM59201 2,3-dihydro-1H-4-oxa-2,5-diazaphenanthrenes, 3.2

SMILES: Clc1cc2CN(Oc2c2ncccc12)C1CCN(Cc2ccc(cc2)-c2ccccc2)CC1

InChI Key: InChIKey=KZTRSZLIJNIRDO-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 59201   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent-like kinase 5 (Homo sapiens (Human))	BDBM59201 (2,3-dihydro-1H-4-oxa-2,5-diazaphenanthrenes, 3.2) Show SMILES Clc1cc2CN(Oc2c2ncccc12)C1CCN(Cc2ccc(cc2)-c2ccccc2)CC1 Show InChI InChI=1S/C28H26ClN3O/c29-26-17-23-19-32(33-28(23)27-25(26)7-4-14-30-27)24-12-15-31(16-13-24)18-20-8-10-22(11-9-20)21-5-2-1-3-6-21/h1-11,14,17,24H,12-13,15-16,18-19H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School					Assay Description Cdk5, 33P-ATP and cofactors were added in the presence of tau protein. The reaction mixture was incubated to allow Cdk5 to transfer 33P from ATP to ...				Chem Biol 12: 811-23 (2005) Article DOI: 10.1016/j.chembiol.2005.05.011 BindingDB Entry DOI: 10.7270/Q2ST7N84
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