BDBM59222 Pepstatin analog, 10
SMILES: CC(C)C[C@@H](NC(=O)[C@H](NC(=O)CCCCCCCCCCCCCCC(=O)N[C@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(O)=O)C(C)O)C(=O)NCCc1ccc(N)cc1
InChI Key: InChIKey=WDNSCOBNNSIZKN-KUMZHBIPSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Human herpesvirus 1 protease (Human herpesvirus 1 (strain 17) (HHV-1) (Human her...) | BDBM59222 (Pepstatin analog, 10) | MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 650 | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | 5.52 | n/a |
Purdue University | Assay Description A zhang-poorman assay confirms a competitive inhibition mechanism or inhibit HIV-1 PR as a dimerization or mixed type inhibitor. | Chem Biol 12: 439-44 (2005) Article DOI: 10.1016/j.chembiol.2005.02.004 BindingDB Entry DOI: 10.7270/Q2JD4V68 | |||||||||||
More data for this Ligand-Target Pair |