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SMILES: CC(C)(C)n1cc(-c2cc(on2)C2CC2)c2c(N)ncnc12

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 597649   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM597649 (US11603374, Example 4) Show SMILES CC(C)(C)n1cc(-c2cc(on2)C2CC2)c2c(N)ncnc12 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The potency of compounds inhibiting several different RET kinase forms (Wild Type, V804M, M918T, G810R, & G810S) were determined using CisBio's H...				Citation and Details BindingDB Entry DOI: 10.7270/Q2Z323KZ
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [V804M] (Homo sapiens (Human))	BDBM597649 (US11603374, Example 4) Show SMILES CC(C)(C)n1cc(-c2cc(on2)C2CC2)c2c(N)ncnc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The potency of compounds inhibiting several different RET kinase forms (Wild Type, V804M, M918T, G810R, & G810S) were determined using CisBio's H...				Citation and Details BindingDB Entry DOI: 10.7270/Q2Z323KZ
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [G810S] (Homo sapiens (Human))	BDBM597649 (US11603374, Example 4) Show SMILES CC(C)(C)n1cc(-c2cc(on2)C2CC2)c2c(N)ncnc12 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10.4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The potency of compounds inhibiting several different RET kinase forms (Wild Type, V804M, M918T, G810R, & G810S) were determined using CisBio's H...				Citation and Details BindingDB Entry DOI: 10.7270/Q2Z323KZ
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [G810R] (Homo sapiens (Human))	BDBM597649 (US11603374, Example 4) Show SMILES CC(C)(C)n1cc(-c2cc(on2)C2CC2)c2c(N)ncnc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The potency of compounds inhibiting several different RET kinase forms (Wild Type, V804M, M918T, G810R, & G810S) were determined using CisBio's H...				Citation and Details BindingDB Entry DOI: 10.7270/Q2Z323KZ
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [M918T] (Homo sapiens (Human))	BDBM597649 (US11603374, Example 4) Show SMILES CC(C)(C)n1cc(-c2cc(on2)C2CC2)c2c(N)ncnc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The potency of compounds inhibiting several different RET kinase forms (Wild Type, V804M, M918T, G810R, & G810S) were determined using CisBio's H...				Citation and Details BindingDB Entry DOI: 10.7270/Q2Z323KZ
					More data for this Ligand-Target Pair