null
SMILES: COCc1nn(Cc2cnc3CN(C)CCc3c2)cc1C(=O)NCc1c(F)c(OC)ccc1-n1cc(C)nn1
InChI Key:
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Plasma kallikrein (Homo sapiens (Human)) | BDBM598461 (N-{[2-fluoro-3-methoxy-6-(4-methyl-1,2,3-triazol-1...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8... | Citation and Details BindingDB Entry DOI: 10.7270/Q2RF5ZZZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor XI (Homo sapiens (Human)) | BDBM598461 (N-{[2-fluoro-3-methoxy-6-(4-methyl-1,2,3-triazol-1...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.42E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description FXIa inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8, 185; Shori ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2RF5ZZZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kallikrein-1 (Homo sapiens (Human)) | BDBM598461 (N-{[2-fluoro-3-methoxy-6-(4-methyl-1,2,3-triazol-1...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description KLK1 inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8, 185; Shori ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2RF5ZZZ | |||||||||||
More data for this Ligand-Target Pair |