BDBM60650 US9145391, 23

SMILES: CN=C.[H][C@@]1(CC[C@H](CO)CC1)C(C)(O)c1ccc(cn1)-c1cc(C)cc(Nc2cc(ccn2)C(F)F)n1

InChI Key: InChIKey=WFRKFVOJBMYXSG-UGJODJQVSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 60650   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM60650 (US9145391, 23) Show SMILES CN=C.[H][C@@]1(CC[C@H](CO)CC1)C(C)(O)c1ccc(cn1)-c1cc(C)cc(Nc2cc(ccn2)C(F)F)n1 |r,wD:4.2,7.6,(6.64,-4.64,;7.41,-3.31,;6.64,-1.97,;-4.95,-.87,;-3.62,-1.64,;-3.62,-.1,;-2.28,.67,;-.95,-.1,;.39,.67,;1.72,-.1,;-.95,-1.64,;-2.28,-2.41,;-4.95,-2.41,;-3.62,-3.18,;-4.95,-3.95,;-6.28,-1.64,;-7.62,-2.41,;-8.95,-1.64,;-8.95,-.1,;-7.62,.67,;-6.28,-.1,;-10.28,.67,;-11.62,-.1,;-12.95,.67,;-14.29,-.1,;-12.95,2.21,;-11.62,2.98,;-11.62,4.52,;-10.28,5.29,;-8.95,4.52,;-7.62,5.29,;-7.62,6.83,;-8.95,7.6,;-10.28,6.83,;-6.28,4.52,;-4.95,5.29,;-6.27,2.92,;-10.28,2.21,)| Show InChI InChI=1S/C26H30F2N4O2.C2H5N/c1-16-11-21(31-24(12-16)32-23-13-18(25(27)28)9-10-29-23)19-5-8-22(30-14-19)26(2,34)20-6-3-17(15-33)4-7-20;1-3-2/h5,8-14,17,20,25,33-34H,3-4,6-7,15H2,1-2H3,(H,29,31,32);1H2,2H3/t17-,20-,26?;	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	7.5	25
Merck Sharp & Dohme Corp.; Merck Canada Inc. US Patent					Assay Description A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...				US Patent US9145391 (2015) BindingDB Entry DOI: 10.7270/Q2SQ8Z5V
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