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SMILES: CNc1nc(Nc2ccc(cc2OC)S(C)(=O)=O)ncc1Cl

InChI Key: InChIKey=LZFHWFCVSZKXIP-UHFFFAOYSA-N

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 60653   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM60653
PNG
(US9145402, 2)
Show SMILES CNc1nc(Nc2ccc(cc2OC)S(C)(=O)=O)ncc1Cl
Show InChI InChI=1S/C13H15ClN4O3S/c1-15-12-9(14)7-16-13(18-12)17-10-5-4-8(22(3,19)20)6-11(10)21-2/h4-7H,1-3H3,(H2,15,16,17,18)
PDB

KEGG

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Similars
US Patent
 2n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 3...

US Patent US9145402 (2015)


BindingDB Entry DOI: 10.7270/Q2J67FQ3
More data for this
Ligand-Target Pair