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SMILES: CC[C@@H](N[C@H](C)CO)c1ccc(Cl)c(C(=O)c2cccnc2)c1F

InChI Key: InChIKey=AMNLKVFPQJHGHN-IAQYHMDHSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 60692   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Genome polyprotein


(Hepatitis C virus (HCV genotype 1a, isolate H))		BDBM60692
PNG
(US9145354, 166)
Show SMILES CC[C@@H](N[C@H](C)CO)c1ccc(Cl)c(C(=O)c2cccnc2)c1F |r|
Show InChI InChI=1S/C18H20ClFN2O2/c1-3-15(22-11(2)10-23)13-6-7-14(19)16(17(13)20)18(24)12-5-4-8-21-9-12/h4-9,11,15,22-23H,3,10H2,1-2H3/t11-,15-/m1/s1
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Similars
US Patent
n/an/a 6.30E+3n/an/an/an/an/a25



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
The HCV NS3 protease functions have been extensively studied and are considered as potential targets for antiviral therapy: see for example the many ...

US Patent US9145354 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MMZ
More data for this
Ligand-Target Pair