BDBM60799 US9163021, 172

SMILES: CC(C)n1cc(C(=O)c2ccnc(NC(=O)Cc3ccc(c(F)c3)C(F)(F)F)c2)c2cnccc12

InChI Key: InChIKey=VGVNZKACTWCQMO-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 60799   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM60799 (US9163021, 172) Show SMILES CC(C)n1cc(C(=O)c2ccnc(NC(=O)Cc3ccc(c(F)c3)C(F)(F)F)c2)c2cnccc12 Show InChI InChI=1S/C25H20F4N4O2/c1-14(2)33-13-18(17-12-30-7-6-21(17)33)24(35)16-5-8-31-22(11-16)32-23(34)10-15-3-4-19(20(26)9-15)25(27,28)29/h3-9,11-14H,10H2,1-2H3,(H,31,32,34)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8.49	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Limited US Patent					Assay Description Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...				US Patent US9163021 (2015) BindingDB Entry DOI: 10.7270/Q29C6W7C
					More data for this Ligand-Target Pair