null

SMILES: COc1ncc(Cl)cc1S(=O)(=O)Nc1ccc(F)c(C#Cc2cnc(N)nc2)c1F

InChI Key:

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 615001   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
eIF-2-alpha kinase GCN2 (Homo sapiens (Human))	BDBM615001 (US20230271939, Comp Ex 1) Show SMILES COc1ncc(Cl)cc1S(=O)(=O)Nc1ccc(F)c(C#Cc2cnc(N)nc2)c1F Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	MCE PC cid PC sid PDB UniChem	PDB US Patent	0.900	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent									US Patent US10174003 (2019) BindingDB Entry DOI: 10.7270/Q2Q244CX
					More data for this Ligand-Target Pair				3D Structure (crystal)
eIF-2-alpha kinase GCN2 (Homo sapiens (Human))	BDBM615001 (US20230271939, Comp Ex 1) Show SMILES COc1ncc(Cl)cc1S(=O)(=O)Nc1ccc(F)c(C#Cc2cnc(N)nc2)c1F Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	MCE PC cid PC sid PDB UniChem	PDB US Patent	1.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent									US Patent US10174003 (2019) BindingDB Entry DOI: 10.7270/Q2Q244CX
					More data for this Ligand-Target Pair				3D Structure (crystal)
eIF-2-alpha kinase GCN2 (Homo sapiens (Human))	BDBM615001 (US20230271939, Comp Ex 1) Show SMILES COc1ncc(Cl)cc1S(=O)(=O)Nc1ccc(F)c(C#Cc2cnc(N)nc2)c1F Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	MCE PC cid PC sid PDB UniChem	PDB US Patent	n/a	n/a	59.2	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent									US Patent US10174003 (2019) BindingDB Entry DOI: 10.7270/Q2Q244CX
					More data for this Ligand-Target Pair				3D Structure (crystal)
eIF-2-alpha kinase GCN2 (Homo sapiens (Human))	BDBM615001 (US20230271939, Comp Ex 1) Show SMILES COc1ncc(Cl)cc1S(=O)(=O)Nc1ccc(F)c(C#Cc2cnc(N)nc2)c1F Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	MCE PC cid PC sid PDB UniChem	PDB US Patent	n/a	n/a	5.90	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent									US Patent US10174003 (2019) BindingDB Entry DOI: 10.7270/Q2Q244CX
					More data for this Ligand-Target Pair				3D Structure (crystal)