null

SMILES: CCNC(=O)Nc1nc2cc(NCCCCN(CC)CC)ncc2cc1-c1cc(OC)cc(OC)c1

InChI Key: InChIKey=QTMASMKMHNYBIC-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 6153   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Platelet-derived growth factor receptor beta (Mus musculus (mouse))	BDBM6153 (1,6-naphthyridine 22 | 1-(7-{[4-(diethylamino)buty...) Show SMILES CCNC(=O)Nc1nc2cc(NCCCCN(CC)CC)ncc2cc1-c1cc(OC)cc(OC)c1 Show InChI InChI=1S/C27H38N6O3/c1-6-28-27(34)32-26-23(19-13-21(35-4)16-22(14-19)36-5)15-20-18-30-25(17-24(20)31-26)29-11-9-10-12-33(7-2)8-3/h13-18H,6-12H2,1-5H3,(H,29,30)(H2,28,31,32,34)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland					Assay Description Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...				J Med Chem 48: 4628-53 (2005) Article DOI: 10.1021/jm0500931 BindingDB Entry DOI: 10.7270/Q2DV1H3W
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM6153 (1,6-naphthyridine 22 | 1-(7-{[4-(diethylamino)buty...) Show SMILES CCNC(=O)Nc1nc2cc(NCCCCN(CC)CC)ncc2cc1-c1cc(OC)cc(OC)c1 Show InChI InChI=1S/C27H38N6O3/c1-6-28-27(34)32-26-23(19-13-21(35-4)16-22(14-19)36-5)15-20-18-30-25(17-24(20)31-26)29-11-9-10-12-33(7-2)8-3/h13-18H,6-12H2,1-5H3,(H,29,30)(H2,28,31,32,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	46	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland					Assay Description Tha assay was using human VEGFR-2 in DELFIA (dissociation-enhanced lanthanide fluoroimmunoassay) format. IC50 is the concentration of inhibitor that ...				J Med Chem 48: 4628-53 (2005) Article DOI: 10.1021/jm0500931 BindingDB Entry DOI: 10.7270/Q2DV1H3W
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM6153 (1,6-naphthyridine 22 | 1-(7-{[4-(diethylamino)buty...) Show SMILES CCNC(=O)Nc1nc2cc(NCCCCN(CC)CC)ncc2cc1-c1cc(OC)cc(OC)c1 Show InChI InChI=1S/C27H38N6O3/c1-6-28-27(34)32-26-23(19-13-21(35-4)16-22(14-19)36-5)15-20-18-30-25(17-24(20)31-26)29-11-9-10-12-33(7-2)8-3/h13-18H,6-12H2,1-5H3,(H,29,30)(H2,28,31,32,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland					Assay Description Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...				J Med Chem 48: 4628-53 (2005) Article DOI: 10.1021/jm0500931 BindingDB Entry DOI: 10.7270/Q2DV1H3W
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM6153 (1,6-naphthyridine 22 | 1-(7-{[4-(diethylamino)buty...) Show SMILES CCNC(=O)Nc1nc2cc(NCCCCN(CC)CC)ncc2cc1-c1cc(OC)cc(OC)c1 Show InChI InChI=1S/C27H38N6O3/c1-6-28-27(34)32-26-23(19-13-21(35-4)16-22(14-19)36-5)15-20-18-30-25(17-24(20)31-26)29-11-9-10-12-33(7-2)8-3/h13-18H,6-12H2,1-5H3,(H,29,30)(H2,28,31,32,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland					Assay Description Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...				J Med Chem 48: 4628-53 (2005) Article DOI: 10.1021/jm0500931 BindingDB Entry DOI: 10.7270/Q2DV1H3W
					More data for this Ligand-Target Pair