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SMILES: CN1CCN(CCCNc2cc3nc(NCCCN4CCN(C)CC4)c(cc3cn2)-c2ccccc2)CC1

InChI Key: InChIKey=FYWYYGLUFUROPO-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 6160   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Platelet-derived growth factor receptor beta (Mus musculus (mouse))	BDBM6160 (1,6-naphthyridine 29 | 2-N,7-N-bis[3-(4-methylpipe...) Show SMILES CN1CCN(CCCNc2cc3nc(NCCCN4CCN(C)CC4)c(cc3cn2)-c2ccccc2)CC1 Show InChI InChI=1S/C30H44N8/c1-35-14-18-37(19-15-35)12-6-10-31-29-23-28-26(24-33-29)22-27(25-8-4-3-5-9-25)30(34-28)32-11-7-13-38-20-16-36(2)17-21-38/h3-5,8-9,22-24H,6-7,10-21H2,1-2H3,(H,31,33)(H,32,34)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland					Assay Description Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...				J Med Chem 48: 4628-53 (2005) Article DOI: 10.1021/jm0500931 BindingDB Entry DOI: 10.7270/Q2DV1H3W
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM6160 (1,6-naphthyridine 29 | 2-N,7-N-bis[3-(4-methylpipe...) Show SMILES CN1CCN(CCCNc2cc3nc(NCCCN4CCN(C)CC4)c(cc3cn2)-c2ccccc2)CC1 Show InChI InChI=1S/C30H44N8/c1-35-14-18-37(19-15-35)12-6-10-31-29-23-28-26(24-33-29)22-27(25-8-4-3-5-9-25)30(34-28)32-11-7-13-38-20-16-36(2)17-21-38/h3-5,8-9,22-24H,6-7,10-21H2,1-2H3,(H,31,33)(H,32,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland					Assay Description Tha assay was using human VEGFR-2 in DELFIA (dissociation-enhanced lanthanide fluoroimmunoassay) format. IC50 is the concentration of inhibitor that ...				J Med Chem 48: 4628-53 (2005) Article DOI: 10.1021/jm0500931 BindingDB Entry DOI: 10.7270/Q2DV1H3W
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM6160 (1,6-naphthyridine 29 | 2-N,7-N-bis[3-(4-methylpipe...) Show SMILES CN1CCN(CCCNc2cc3nc(NCCCN4CCN(C)CC4)c(cc3cn2)-c2ccccc2)CC1 Show InChI InChI=1S/C30H44N8/c1-35-14-18-37(19-15-35)12-6-10-31-29-23-28-26(24-33-29)22-27(25-8-4-3-5-9-25)30(34-28)32-11-7-13-38-20-16-36(2)17-21-38/h3-5,8-9,22-24H,6-7,10-21H2,1-2H3,(H,31,33)(H,32,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland					Assay Description Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...				J Med Chem 48: 4628-53 (2005) Article DOI: 10.1021/jm0500931 BindingDB Entry DOI: 10.7270/Q2DV1H3W
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM6160 (1,6-naphthyridine 29 | 2-N,7-N-bis[3-(4-methylpipe...) Show SMILES CN1CCN(CCCNc2cc3nc(NCCCN4CCN(C)CC4)c(cc3cn2)-c2ccccc2)CC1 Show InChI InChI=1S/C30H44N8/c1-35-14-18-37(19-15-35)12-6-10-31-29-23-28-26(24-33-29)22-27(25-8-4-3-5-9-25)30(34-28)32-11-7-13-38-20-16-36(2)17-21-38/h3-5,8-9,22-24H,6-7,10-21H2,1-2H3,(H,31,33)(H,32,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland					Assay Description Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...				J Med Chem 48: 4628-53 (2005) Article DOI: 10.1021/jm0500931 BindingDB Entry DOI: 10.7270/Q2DV1H3W
					More data for this Ligand-Target Pair