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SMILES: FC(F)c1ccc2ncc(-c3cccc(N[C@H]4CNC[C@@H]4F)n3)n2c1

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 621123   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Interleukin-1 receptor-associated kinase 1 (Homo sapiens (Human))	BDBM621123 (US20230303563, Compound 165) Show SMILES FC(F)c1ccc2ncc(-c3cccc(N[C@H]4CNC[C@@H]4F)n3)n2c1 |r| Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
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Interleukin-1 receptor-associated kinase 4 (Homo sapiens (Human))	BDBM621123 (US20230303563, Compound 165) Show SMILES FC(F)c1ccc2ncc(-c3cccc(N[C@H]4CNC[C@@H]4F)n3)n2c1 |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
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Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM621123 (US20230303563, Compound 165) Show SMILES FC(F)c1ccc2ncc(-c3cccc(N[C@H]4CNC[C@@H]4F)n3)n2c1 |r| Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
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Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM621123 (US20230303563, Compound 165) Show SMILES FC(F)c1ccc2ncc(-c3cccc(N[C@H]4CNC[C@@H]4F)n3)n2c1 |r| Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	n/a	0.170	n/a	n/a	n/a	n/a	n/a
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Receptor-type tyrosine-protein kinase FLT3 [D835H] (Homo sapiens (Human))	BDBM621123 (US20230303563, Compound 165) Show SMILES FC(F)c1ccc2ncc(-c3cccc(N[C@H]4CNC[C@@H]4F)n3)n2c1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	n/a	0.240	n/a	n/a	n/a	n/a	n/a
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Receptor-type tyrosine-protein kinase FLT3 [D835V] (Homo sapiens (Human))	BDBM621123 (US20230303563, Compound 165) Show SMILES FC(F)c1ccc2ncc(-c3cccc(N[C@H]4CNC[C@@H]4F)n3)n2c1 |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	n/a	0.0250	n/a	n/a	n/a	n/a	n/a
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Receptor-type tyrosine-protein kinase FLT3 [572-603] (Homo sapiens (Human))	BDBM621123 (US20230303563, Compound 165) Show SMILES FC(F)c1ccc2ncc(-c3cccc(N[C@H]4CNC[C@@H]4F)n3)n2c1 |r| Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	n/a	4.90	n/a	n/a	n/a	n/a	n/a
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Dimer of Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM621123 (US20230303563, Compound 165) Show SMILES FC(F)c1ccc2ncc(-c3cccc(N[C@H]4CNC[C@@H]4F)n3)n2c1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	n/a	0.150	n/a	n/a	n/a	n/a	n/a
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Dimer of Receptor-type tyrosine-protein kinase FLT3 [D835V] (Homo sapiens (Human))	BDBM621123 (US20230303563, Compound 165) Show SMILES FC(F)c1ccc2ncc(-c3cccc(N[C@H]4CNC[C@@H]4F)n3)n2c1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	n/a	0.00700	n/a	n/a	n/a	n/a	n/a
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Dimer of Receptor-type tyrosine-protein kinase FLT3 [F691L] (Homo sapiens (Human))	BDBM621123 (US20230303563, Compound 165) Show SMILES FC(F)c1ccc2ncc(-c3cccc(N[C@H]4CNC[C@@H]4F)n3)n2c1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	n/a	0.190	n/a	n/a	n/a	n/a	n/a
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Receptor-type tyrosine-protein kinase FLT3 [K663Q] (Homo sapiens (Human))	BDBM621123 (US20230303563, Compound 165) Show SMILES FC(F)c1ccc2ncc(-c3cccc(N[C@H]4CNC[C@@H]4F)n3)n2c1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a
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Receptor-type tyrosine-protein kinase FLT3 [N841I] (Homo sapiens (Human))	BDBM621123 (US20230303563, Compound 165) Show SMILES FC(F)c1ccc2ncc(-c3cccc(N[C@H]4CNC[C@@H]4F)n3)n2c1 |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	n/a	0.740	n/a	n/a	n/a	n/a	n/a
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Receptor-type tyrosine-protein kinase FLT3 [R834Q] (Homo sapiens (Human))	BDBM621123 (US20230303563, Compound 165) Show SMILES FC(F)c1ccc2ncc(-c3cccc(N[C@H]4CNC[C@@H]4F)n3)n2c1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	n/a	0.890	n/a	n/a	n/a	n/a	n/a
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Receptor-type tyrosine-protein kinase FLT3 (D835Y) (Homo sapiens (Human))	BDBM621123 (US20230303563, Compound 165) Show SMILES FC(F)c1ccc2ncc(-c3cccc(N[C@H]4CNC[C@@H]4F)n3)n2c1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	n/a	0.110	n/a	n/a	n/a	n/a	n/a
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