BindingDB PrimarySearch

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SMILES: CC(C)Oc1ccn2c(cnc2c1)-c1nc(N[C@H]2CNC[C@@H]2F)c(F)cc1F

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 621136
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Interleukin-1 receptor-associated kinase 1 (Homo sapiens (Human))	BDBM621136 (3,5-difluoro-N-((3S,4S)-4- fluoropyrrolidin-3-yl)-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
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Interleukin-1 receptor-associated kinase 4 (Homo sapiens (Human))	BDBM621136 (3,5-difluoro-N-((3S,4S)-4- fluoropyrrolidin-3-yl)-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
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TBA				More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM621136 (3,5-difluoro-N-((3S,4S)-4- fluoropyrrolidin-3-yl)-...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM621136 (3,5-difluoro-N-((3S,4S)-4- fluoropyrrolidin-3-yl)-...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	n/a	n/a	n/a	2.30	n/a	n/a	n/a	n/a	n/a
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TBA				More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835H] (Homo sapiens (Human))	BDBM621136 (3,5-difluoro-N-((3S,4S)-4- fluoropyrrolidin-3-yl)-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	n/a	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a
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Receptor-type tyrosine-protein kinase FLT3 [D835V] (Homo sapiens (Human))	BDBM621136 (3,5-difluoro-N-((3S,4S)-4- fluoropyrrolidin-3-yl)-...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	n/a	n/a	n/a	0.25	n/a	n/a	n/a	n/a	n/a
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Receptor-type tyrosine-protein kinase FLT3 [572-603] (Homo sapiens (Human))	BDBM621136 (3,5-difluoro-N-((3S,4S)-4- fluoropyrrolidin-3-yl)-...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	n/a	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a
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TBA				More data for this Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM621136 (3,5-difluoro-N-((3S,4S)-4- fluoropyrrolidin-3-yl)-...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	n/a	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3 [D835V] (Homo sapiens (Human))	BDBM621136 (3,5-difluoro-N-((3S,4S)-4- fluoropyrrolidin-3-yl)-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	n/a	n/a	n/a	0.0490	n/a	n/a	n/a	n/a	n/a
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Dimer of Receptor-type tyrosine-protein kinase FLT3 [F691L] (Homo sapiens (Human))	BDBM621136 (3,5-difluoro-N-((3S,4S)-4- fluoropyrrolidin-3-yl)-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	n/a	n/a	n/a	0.490	n/a	n/a	n/a	n/a	n/a
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Receptor-type tyrosine-protein kinase FLT3 [K663Q] (Homo sapiens (Human))	BDBM621136 (3,5-difluoro-N-((3S,4S)-4- fluoropyrrolidin-3-yl)-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	n/a	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a
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Receptor-type tyrosine-protein kinase FLT3 [N841I] (Homo sapiens (Human))	BDBM621136 (3,5-difluoro-N-((3S,4S)-4- fluoropyrrolidin-3-yl)-...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	n/a	n/a	n/a	8.10	n/a	n/a	n/a	n/a	n/a
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Receptor-type tyrosine-protein kinase FLT3 [R834Q] (Homo sapiens (Human))	BDBM621136 (3,5-difluoro-N-((3S,4S)-4- fluoropyrrolidin-3-yl)-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	n/a	n/a	n/a	8.5	n/a	n/a	n/a	n/a	n/a
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TBA				More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (D835Y) (Homo sapiens (Human))	BDBM621136 (3,5-difluoro-N-((3S,4S)-4- fluoropyrrolidin-3-yl)-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	n/a	n/a	n/a	0.960	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair