BindingDB PrimarySearch

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SMILES: CC(C)Oc1ccn2c(cnc2c1)-c1cccc(N[C@H]2CNC[C@@H]2F)n1

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 621161
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Interleukin-1 receptor-associated kinase 1 (Homo sapiens (Human))	BDBM621161 (N-((3S,4S)-4- fluoropyrrolidin-3-yl)-6-(7- isoprop...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
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Interleukin-1 receptor-associated kinase 4 (Homo sapiens (Human))	BDBM621161 (N-((3S,4S)-4- fluoropyrrolidin-3-yl)-6-(7- isoprop...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	n/a	n/a	<0.5	n/a	n/a	n/a	n/a	n/a	n/a
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Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM621161 (N-((3S,4S)-4- fluoropyrrolidin-3-yl)-6-(7- isoprop...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	n/a	n/a	<0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM621161 (N-((3S,4S)-4- fluoropyrrolidin-3-yl)-6-(7- isoprop...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	n/a	n/a	n/a	0.210	n/a	n/a	n/a	n/a	n/a
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Receptor-type tyrosine-protein kinase FLT3 [D835H] (Homo sapiens (Human))	BDBM621161 (N-((3S,4S)-4- fluoropyrrolidin-3-yl)-6-(7- isoprop...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	n/a	n/a	n/a	0.260	n/a	n/a	n/a	n/a	n/a
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Receptor-type tyrosine-protein kinase FLT3 [D835V] (Homo sapiens (Human))	BDBM621161 (N-((3S,4S)-4- fluoropyrrolidin-3-yl)-6-(7- isoprop...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	n/a	n/a	n/a	0.0690	n/a	n/a	n/a	n/a	n/a
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Receptor-type tyrosine-protein kinase FLT3 [572-603] (Homo sapiens (Human))	BDBM621161 (N-((3S,4S)-4- fluoropyrrolidin-3-yl)-6-(7- isoprop...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	n/a	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a
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Dimer of Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM621161 (N-((3S,4S)-4- fluoropyrrolidin-3-yl)-6-(7- isoprop...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	n/a	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a
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Dimer of Receptor-type tyrosine-protein kinase FLT3 [D835V] (Homo sapiens (Human))	BDBM621161 (N-((3S,4S)-4- fluoropyrrolidin-3-yl)-6-(7- isoprop...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	n/a	n/a	n/a	0.0180	n/a	n/a	n/a	n/a	n/a
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Dimer of Receptor-type tyrosine-protein kinase FLT3 [F691L] (Homo sapiens (Human))	BDBM621161 (N-((3S,4S)-4- fluoropyrrolidin-3-yl)-6-(7- isoprop...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	n/a	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a
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Receptor-type tyrosine-protein kinase FLT3 [K663Q] (Homo sapiens (Human))	BDBM621161 (N-((3S,4S)-4- fluoropyrrolidin-3-yl)-6-(7- isoprop...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	n/a	n/a	n/a	0.450	n/a	n/a	n/a	n/a	n/a
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Receptor-type tyrosine-protein kinase FLT3 [N841I] (Homo sapiens (Human))	BDBM621161 (N-((3S,4S)-4- fluoropyrrolidin-3-yl)-6-(7- isoprop...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	n/a	n/a	n/a	0.910	n/a	n/a	n/a	n/a	n/a
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Receptor-type tyrosine-protein kinase FLT3 [R834Q] (Homo sapiens (Human))	BDBM621161 (N-((3S,4S)-4- fluoropyrrolidin-3-yl)-6-(7- isoprop...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	n/a	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a
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Receptor-type tyrosine-protein kinase FLT3 (D835Y) (Homo sapiens (Human))	BDBM621161 (N-((3S,4S)-4- fluoropyrrolidin-3-yl)-6-(7- isoprop...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	n/a	n/a	n/a	0.330	n/a	n/a	n/a	n/a	n/a
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