BDBM6212 Benzodioxole deriv. 21::N-(5-Fluoro-1,3-benzodioxol-4-yl)-6-methoxy-7-(3-morpholin-4-ylpropoxy)quinazolin-4-amine::N-(5-fluoro-2H-1,3-benzodioxol-4-yl)-6-methoxy-7-[3-(morpholin-4-yl)propoxy]quinazolin-4-amine

SMILES: COc1cc2c(Nc3c4OCOc4ccc3F)ncnc2cc1OCCCN1CCOCC1

InChI Key: InChIKey=IRRKXQSEZMFNPY-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 6212   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM6212 (Benzodioxole deriv. 21 | N-(5-Fluoro-1,3-benzodiox...) Show SMILES COc1cc2c(Nc3c4OCOc4ccc3F)ncnc2cc1OCCCN1CCOCC1 Show InChI InChI=1S/C23H25FN4O5/c1-29-19-11-15-17(12-20(19)31-8-2-5-28-6-9-30-10-7-28)25-13-26-23(15)27-21-16(24)3-4-18-22(21)33-14-32-18/h3-4,11-13H,2,5-10,14H2,1H3,(H,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.16E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca					Assay Description An ELISA assay was used to determine the ability of inhibitor to inhibit receptor tyrosine kinase activity. The compounds were incubated with enzym...				J Med Chem 47: 871-87 (2004) Article DOI: 10.1021/jm030317k BindingDB Entry DOI: 10.7270/Q2930RCG
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM6212 (Benzodioxole deriv. 21 | N-(5-Fluoro-1,3-benzodiox...) Show SMILES COc1cc2c(Nc3c4OCOc4ccc3F)ncnc2cc1OCCCN1CCOCC1 Show InChI InChI=1S/C23H25FN4O5/c1-29-19-11-15-17(12-20(19)31-8-2-5-28-6-9-30-10-7-28)25-13-26-23(15)27-21-16(24)3-4-18-22(21)33-14-32-18/h3-4,11-13H,2,5-10,14H2,1H3,(H,25,26,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca					Assay Description This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...				J Med Chem 47: 871-87 (2004) Article DOI: 10.1021/jm030317k BindingDB Entry DOI: 10.7270/Q2930RCG
					More data for this Ligand-Target Pair