BDBM6235 2-(3,4-Dimethoxyphenylamino)-8-ethyl-8H-pyrido[2,3-d]pyrimidin-7-one::2-[(3,4-dimethoxyphenyl)amino]-8-ethyl-7H,8H-pyrido[2,3-d]pyrimidin-7-one::C2 Pyrido[2,3-d]pyrimidin-7-one deriv. 27

SMILES: CCn1c2nc(Nc3ccc(OC)c(OC)c3)ncc2ccc1=O

InChI Key: InChIKey=SVJNWILXZCNIRZ-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 6235   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C] (Homo sapiens (Human))	BDBM6235 (2-(3,4-Dimethoxyphenylamino)-8-ethyl-8H-pyrido[2,3...) Show SMILES CCn1c2nc(Nc3ccc(OC)c(OC)c3)ncc2ccc1=O Show InChI InChI=1S/C17H18N4O3/c1-4-21-15(22)8-5-11-10-18-17(20-16(11)21)19-12-6-7-13(23-2)14(9-12)24-3/h5-10H,4H2,1-3H3,(H,18,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.08E+3	n/a	n/a	n/a	n/a	7.4	25
Parke-Davis Pharmaceutical Research					Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...				J Med Chem 43: 4606-16 (2000) Article DOI: 10.1021/jm000271k BindingDB Entry DOI: 10.7270/Q25B00N4
					More data for this Ligand-Target Pair