BDBM6238 2-({4-[2-(diethylamino)ethoxy]phenyl}amino)-8-ethyl-7H,8H-pyrido[2,3-d]pyrimidin-7-one::2-[4-(2-Diethylaminoethoxy)phenylamino]-8-ethyl-8H-pyrido[2,3-d]pyrimidin-7-one::C2 Pyrido[2,3-d]pyrimidin-7-one deriv. 30

SMILES: CCN(CC)CCOc1ccc(Nc2ncc3ccc(=O)n(CC)c3n2)cc1

InChI Key: InChIKey=QIQYKWBRXRSSNC-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 6238   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-Dependent Kinase 4 (CDK4) (Homo sapiens (Human))	BDBM6238 (2-({4-[2-(diethylamino)ethoxy]phenyl}amino)-8-ethy...) Show SMILES CCN(CC)CCOc1ccc(Nc2ncc3ccc(=O)n(CC)c3n2)cc1 Show InChI InChI=1S/C21H27N5O2/c1-4-25(5-2)13-14-28-18-10-8-17(9-11-18)23-21-22-15-16-7-12-19(27)26(6-3)20(16)24-21/h7-12,15H,4-6,13-14H2,1-3H3,(H,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	160	n/a	n/a	n/a	n/a	7.4	25
Parke-Davis Pharmaceutical Research					Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...				J Med Chem 43: 4606-16 (2000) Article DOI: 10.1021/jm000271k BindingDB Entry DOI: 10.7270/Q25B00N4
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