BDBM6244 8-Ethyl-2-{4-[4-(3-hydroxypropyl)piperazin-1-yl]phenylamino}-8H-pyrido[2,3-d]pyrimidin-7-one::8-ethyl-2-({4-[4-(3-hydroxypropyl)piperidin-1-yl]phenyl}amino)-7H,8H-pyrido[2,3-d]pyrimidin-7-one::C2 Pyrido[2,3-d]pyrimidin-7-one deriv. 36

SMILES: CCn1c2nc(Nc3ccc(cc3)N3CCC(CCCO)CC3)ncc2ccc1=O

InChI Key: InChIKey=NNAOBZFDMGBSMB-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 6244   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C] (Homo sapiens (Human))	BDBM6244 (8-Ethyl-2-{4-[4-(3-hydroxypropyl)piperazin-1-yl]ph...) Show SMILES CCn1c2nc(Nc3ccc(cc3)N3CCC(CCCO)CC3)ncc2ccc1=O Show InChI InChI=1S/C23H29N5O2/c1-2-28-21(30)10-5-18-16-24-23(26-22(18)28)25-19-6-8-20(9-7-19)27-13-11-17(12-14-27)4-3-15-29/h5-10,16-17,29H,2-4,11-15H2,1H3,(H,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	900	n/a	n/a	n/a	n/a	n/a	n/a
Parke-Davis Pharmaceutical Research					Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...				J Med Chem 43: 4606-16 (2000) Article DOI: 10.1021/jm000271k BindingDB Entry DOI: 10.7270/Q25B00N4
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