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SMILES: COc1ccc(CN2CCC(CC2)Nc2ccc(cn2)-c2cc(cn3ncc(C#N)c23)-c2cnn(C)c2)cn1

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 625341   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM625341 (US20230322769, Compound 21) Show SMILES COc1ccc(CN2CCC(CC2)Nc2ccc(cn2)-c2cc(cn3ncc(C#N)c23)-c2cnn(C)c2)cn1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	45	n/a	n/a	n/a	n/a	n/a	n/a
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Proto-oncogene tyrosine-protein kinase receptor Ret [V804M] (Homo sapiens (Human))	BDBM625341 (US20230322769, Compound 21) Show SMILES COc1ccc(CN2CCC(CC2)Nc2ccc(cn2)-c2cc(cn3ncc(C#N)c23)-c2cnn(C)c2)cn1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	188	n/a	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM625341 (US20230322769, Compound 21) Show SMILES COc1ccc(CN2CCC(CC2)Nc2ccc(cn2)-c2cc(cn3ncc(C#N)c23)-c2cnn(C)c2)cn1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	109	n/a	n/a	n/a	n/a	n/a	n/a
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Coiled-coil domain-containing protein 6/Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM625341 (US20230322769, Compound 21) Show SMILES COc1ccc(CN2CCC(CC2)Nc2ccc(cn2)-c2cc(cn3ncc(C#N)c23)-c2cnn(C)c2)cn1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	60.5	n/a	n/a	n/a	n/a	n/a	n/a
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Proto-oncogene tyrosine-protein kinase receptor Ret [M918T] (Homo sapiens (Human))	BDBM625341 (US20230322769, Compound 21) Show SMILES COc1ccc(CN2CCC(CC2)Nc2ccc(cn2)-c2cc(cn3ncc(C#N)c23)-c2cnn(C)c2)cn1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
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