BDBM6259 8-Benzyl-2-phenylamino-8H-pyrido[2,3-d]pyrimidin-7-one::8-benzyl-2-(phenylamino)-7H,8H-pyrido[2,3-d]pyrimidin-7-one::N8 Pyrido[2,3-d]pyrimidin-7-one deriv. 51

SMILES: O=c1ccc2cnc(Nc3ccccc3)nc2n1Cc1ccccc1

InChI Key: InChIKey=MHZCBYNKWGSPEP-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 6259   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-Dependent Kinase 4 (CDK4) (Homo sapiens (Human))	BDBM6259 (8-Benzyl-2-phenylamino-8H-pyrido[2,3-d]pyrimidin-7...) Show SMILES O=c1ccc2cnc(Nc3ccccc3)nc2n1Cc1ccccc1 Show InChI InChI=1S/C20H16N4O/c25-18-12-11-16-13-21-20(22-17-9-5-2-6-10-17)23-19(16)24(18)14-15-7-3-1-4-8-15/h1-13H,14H2,(H,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	940	n/a	n/a	n/a	n/a	n/a	n/a
Parke-Davis Pharmaceutical Research					Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...				J Med Chem 43: 4606-16 (2000) Article DOI: 10.1021/jm000271k BindingDB Entry DOI: 10.7270/Q25B00N4
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