BDBM6269 8-Bicyclo[2.2.1]hept-2-yl-2-[4-(2-diethylaminoethoxy)phenylamino]-8H-pyrido[2,3-d]pyrimidin-7-one::8-{bicyclo[2.2.1]heptan-2-yl}-2-({4-[2-(diethylamino)ethoxy]phenyl}amino)-7H,8H-pyrido[2,3-d]pyrimidin-7-one::N8 Pyrido[2,3-d]pyrimidin-7-one deriv. 61

SMILES: CCN(CC)CCOc1ccc(Nc2ncc3ccc(=O)n(C4CC5CCC4C5)c3n2)cc1

InChI Key: InChIKey=DHOSGLXAUZKCBJ-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 6269   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-Dependent Kinase 4 (CDK4) (Homo sapiens (Human))	BDBM6269 (8-Bicyclo[2.2.1]hept-2-yl-2-[4-(2-diethylaminoetho...) Show SMILES CCN(CC)CCOc1ccc(Nc2ncc3ccc(=O)n(C4CC5CCC4C5)c3n2)cc1 |THB:21:22:25.26:28| Show InChI InChI=1S/C26H33N5O2/c1-3-30(4-2)13-14-33-22-10-8-21(9-11-22)28-26-27-17-20-7-12-24(32)31(25(20)29-26)23-16-18-5-6-19(23)15-18/h7-12,17-19,23H,3-6,13-16H2,1-2H3,(H,27,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	450	n/a	n/a	n/a	n/a	n/a	n/a
Parke-Davis Pharmaceutical Research					Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...				J Med Chem 43: 4606-16 (2000) Article DOI: 10.1021/jm000271k BindingDB Entry DOI: 10.7270/Q25B00N4
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