BDBM6390 3-[(5-{6-[(2-chlorophenyl)amino]pyrazin-2-yl}pyridin-3-yl)amino]propan-1-ol::3-{5-[6-(2-Chloro-phenylamino)-pyrazin-2-yl]-pyridin-3-ylamino}-propan-1-ol::Pyrazine-Pyridine Biheteroaryl 19

SMILES: OCCCNc1cncc(c1)-c1cncc(Nc2ccccc2Cl)n1

InChI Key: InChIKey=OQNHOXSUGWCWDP-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 6390   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
VEGFR-2 (KDR) (Rattus norvegicus (rat))	BDBM6390 (3-[(5-{6-[(2-chlorophenyl)amino]pyrazin-2-yl}pyrid...) Show SMILES OCCCNc1cncc(c1)-c1cncc(Nc2ccccc2Cl)n1 Show InChI InChI=1S/C18H18ClN5O/c19-15-4-1-2-5-16(15)23-18-12-21-11-17(24-18)13-8-14(10-20-9-13)22-6-3-7-25/h1-2,4-5,8-12,22,25H,3,6-7H2,(H,23,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.01E+3	n/a	n/a	n/a	n/a	8.0	30
Johnson & Johnson Pharmaceutical					Assay Description The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...				J Med Chem 48: 4892-909 (2005) Article DOI: 10.1021/jm058205b BindingDB Entry DOI: 10.7270/Q2NC5ZD5
					More data for this Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1) (Homo sapiens (Human))	BDBM6390 (3-[(5-{6-[(2-chlorophenyl)amino]pyrazin-2-yl}pyrid...) Show SMILES OCCCNc1cncc(c1)-c1cncc(Nc2ccccc2Cl)n1 Show InChI InChI=1S/C18H18ClN5O/c19-15-4-1-2-5-16(15)23-18-12-21-11-17(24-18)13-8-14(10-20-9-13)22-6-3-7-25/h1-2,4-5,8-12,22,25H,3,6-7H2,(H,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	8.0	30
Johnson & Johnson Pharmaceutical					Assay Description The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...				J Med Chem 48: 4892-909 (2005) Article DOI: 10.1021/jm058205b BindingDB Entry DOI: 10.7270/Q2NC5ZD5
					More data for this Ligand-Target Pair