BDBM6396 6-(5-aminopyridin-3-yl)-N-(3-chlorophenyl)pyrazin-2-amine::Pyrazine-Pyridine Biheteroaryl 37::[6-(5-Amino-pyridin-3-yl)-pyrazin-2-yl]-(3-chloro-phenyl)-amine

SMILES: Nc1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1

InChI Key: InChIKey=DJAHLZXHKVPSHL-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 6396   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
VEGFR-2 (KDR) (Rattus norvegicus (rat))	BDBM6396 (6-(5-aminopyridin-3-yl)-N-(3-chlorophenyl)pyrazin-...) Show SMILES Nc1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1 Show InChI InChI=1S/C15H12ClN5/c16-11-2-1-3-13(5-11)20-15-9-19-8-14(21-15)10-4-12(17)7-18-6-10/h1-9H,17H2,(H,20,21)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.16E+3	n/a	n/a	n/a	n/a	8.0	30
Johnson & Johnson Pharmaceutical					Assay Description The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...				J Med Chem 48: 4892-909 (2005) Article DOI: 10.1021/jm058205b BindingDB Entry DOI: 10.7270/Q2NC5ZD5
					More data for this Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1) (Homo sapiens (Human))	BDBM6396 (6-(5-aminopyridin-3-yl)-N-(3-chlorophenyl)pyrazin-...) Show SMILES Nc1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1 Show InChI InChI=1S/C15H12ClN5/c16-11-2-1-3-13(5-11)20-15-9-19-8-14(21-15)10-4-12(17)7-18-6-10/h1-9H,17H2,(H,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	8.0	30
Johnson & Johnson Pharmaceutical					Assay Description The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...				J Med Chem 48: 4892-909 (2005) Article DOI: 10.1021/jm058205b BindingDB Entry DOI: 10.7270/Q2NC5ZD5
					More data for this Ligand-Target Pair