BDBM6422 4-[(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyridin-3-yl)amino]-1-(piperidin-1-yl)butan-1-one::4-{5-[6-(3-Chloro-phenylamino)-pyrazin-2-yl]-pyridin-3-ylamino}-1-piperidin-1-yl-butan-1-one::Pyrazine-Pyridine Biheteroaryl 62

SMILES: Clc1cccc(Nc2cncc(n2)-c2cncc(NCCCC(=O)N3CCCCC3)c2)c1

InChI Key: InChIKey=XHUDKIDUXNJFIC-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 6422   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
VEGFR-2 (KDR) (Rattus norvegicus (rat))	BDBM6422 (4-[(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyrid...) Show SMILES Clc1cccc(Nc2cncc(n2)-c2cncc(NCCCC(=O)N3CCCCC3)c2)c1 Show InChI InChI=1S/C24H27ClN6O/c25-19-6-4-7-20(13-19)29-23-17-27-16-22(30-23)18-12-21(15-26-14-18)28-9-5-8-24(32)31-10-2-1-3-11-31/h4,6-7,12-17,28H,1-3,5,8-11H2,(H,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	610	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical					Assay Description The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...				J Med Chem 48: 4892-909 (2005) Article DOI: 10.1021/jm058205b BindingDB Entry DOI: 10.7270/Q2NC5ZD5
					More data for this Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1) (Homo sapiens (Human))	BDBM6422 (4-[(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyrid...) Show SMILES Clc1cccc(Nc2cncc(n2)-c2cncc(NCCCC(=O)N3CCCCC3)c2)c1 Show InChI InChI=1S/C24H27ClN6O/c25-19-6-4-7-20(13-19)29-23-17-27-16-22(30-23)18-12-21(15-26-14-18)28-9-5-8-24(32)31-10-2-1-3-11-31/h4,6-7,12-17,28H,1-3,5,8-11H2,(H,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical					Assay Description The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...				J Med Chem 48: 4892-909 (2005) Article DOI: 10.1021/jm058205b BindingDB Entry DOI: 10.7270/Q2NC5ZD5
					More data for this Ligand-Target Pair