BDBM6485 4-Anilino-7-phenyl-3-quinolinecarbonitrile 15e::4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-{4-[2-(morpholin-4-yl)ethyl]phenyl}quinoline-3-carbonitrile

SMILES: COc1cc(Nc2c(cnc3cc(c(OC)cc23)-c2ccc(CCN3CCOCC3)cc2)C#N)c(Cl)cc1Cl

InChI Key: InChIKey=VZVRQUVRJYCOJH-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 6485   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM6485 (4-Anilino-7-phenyl-3-quinolinecarbonitrile 15e | 4...) Show SMILES COc1cc(Nc2c(cnc3cc(c(OC)cc23)-c2ccc(CCN3CCOCC3)cc2)C#N)c(Cl)cc1Cl Show InChI InChI=1S/C30H28Cl2N4O3/c1-37-28-14-23-26(13-22(28)20-5-3-19(4-6-20)7-8-36-9-11-39-12-10-36)34-18-21(17-33)30(23)35-27-16-29(38-2)25(32)15-24(27)31/h3-6,13-16,18H,7-12H2,1-2H3,(H,34,35)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	7.5	30
Wyeth Research					Assay Description Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...				Bioorg Med Chem Lett 12: 2989-92 (2002) Article DOI: 10.1016/s0960-894x(02)00577-2 BindingDB Entry DOI: 10.7270/Q24B2ZHC
					More data for this Ligand-Target Pair