BDBM6486 4-Anilino-7-phenyl-3-quinolinecarbonitrile 15f::4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-[3-(morpholin-4-ylmethyl)phenyl]quinoline-3-carbonitrile

SMILES: COc1cc(Nc2c(cnc3cc(ccc23)-c2cccc(CN3CCOCC3)c2)C#N)c(Cl)cc1Cl

InChI Key: InChIKey=RQDHXJAKYHOLIQ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 6486   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM6486 (4-Anilino-7-phenyl-3-quinolinecarbonitrile 15f | 4...) Show SMILES COc1cc(Nc2c(cnc3cc(ccc23)-c2cccc(CN3CCOCC3)c2)C#N)c(Cl)cc1Cl Show InChI InChI=1S/C28H24Cl2N4O2/c1-35-27-14-26(23(29)13-24(27)30)33-28-21(15-31)16-32-25-12-20(5-6-22(25)28)19-4-2-3-18(11-19)17-34-7-9-36-10-8-34/h2-6,11-14,16H,7-10,17H2,1H3,(H,32,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	7.5	30
Wyeth Research					Assay Description Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...				Bioorg Med Chem Lett 12: 2989-92 (2002) Article DOI: 10.1016/s0960-894x(02)00577-2 BindingDB Entry DOI: 10.7270/Q24B2ZHC
					More data for this Ligand-Target Pair