BDBM6490 4-Anilino-7-phenyl-3-quinolinecarbonitrile 15j::4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-{4-[2-(morpholin-4-yl)ethyl]phenyl}quinoline-3-carbonitrile

SMILES: COc1cc(Nc2c(cnc3cc(ccc23)-c2ccc(CCN3CCOCC3)cc2)C#N)c(Cl)cc1Cl

InChI Key: InChIKey=QMVFBVREBZUIDM-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 6490   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM6490 (4-Anilino-7-phenyl-3-quinolinecarbonitrile 15j | 4...) Show SMILES COc1cc(Nc2c(cnc3cc(ccc23)-c2ccc(CCN3CCOCC3)cc2)C#N)c(Cl)cc1Cl Show InChI InChI=1S/C29H26Cl2N4O2/c1-36-28-16-27(24(30)15-25(28)31)34-29-22(17-32)18-33-26-14-21(6-7-23(26)29)20-4-2-19(3-5-20)8-9-35-10-12-37-13-11-35/h2-7,14-16,18H,8-13H2,1H3,(H,33,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	7.5	30
Wyeth Research					Assay Description Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...				Bioorg Med Chem Lett 12: 2989-92 (2002) Article DOI: 10.1016/s0960-894x(02)00577-2 BindingDB Entry DOI: 10.7270/Q24B2ZHC
					More data for this Ligand-Target Pair