BDBM6494 4-Anilino-7-phenyl-3-quinolinecarbonitrile 15n::4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-(4-{[4-(2-hydroxyethyl)piperazin-1-yl]methyl}phenyl)quinoline-3-carbonitrile

SMILES: COc1cc(Nc2c(cnc3cc(ccc23)-c2ccc(CN3CCN(CCO)CC3)cc2)C#N)c(Cl)cc1Cl

InChI Key: InChIKey=ADOFRAKFUNLXFZ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 6494   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM6494 (4-Anilino-7-phenyl-3-quinolinecarbonitrile 15n | 4...) Show SMILES COc1cc(Nc2c(cnc3cc(ccc23)-c2ccc(CN3CCN(CCO)CC3)cc2)C#N)c(Cl)cc1Cl Show InChI InChI=1S/C30H29Cl2N5O2/c1-39-29-16-28(25(31)15-26(29)32)35-30-23(17-33)18-34-27-14-22(6-7-24(27)30)21-4-2-20(3-5-21)19-37-10-8-36(9-11-37)12-13-38/h2-7,14-16,18,38H,8-13,19H2,1H3,(H,34,35)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.70	n/a	n/a	n/a	n/a	7.5	30
Wyeth Research					Assay Description Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...				Bioorg Med Chem Lett 12: 2989-92 (2002) Article DOI: 10.1016/s0960-894x(02)00577-2 BindingDB Entry DOI: 10.7270/Q24B2ZHC
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