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SMILES: ONC(=O)CCCCn1cc(C(=O)NCc2ccccc2)c(=O)c2ccccc12

InChI Key: InChIKey=CVRJAKVLEOZKSP-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 65464   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histone deacetylase 1/11/4/6/8


(Homo sapiens (Human))		BDBM65464
PNG
(Quinolone-based HDAC inhibitor 4d)
Show SMILES ONC(=O)CCCCn1cc(C(=O)NCc2ccccc2)c(=O)c2ccccc12
Show InChI InChI=1S/C22H23N3O4/c26-20(24-29)12-6-7-13-25-15-18(21(27)17-10-4-5-11-19(17)25)22(28)23-14-16-8-2-1-3-9-16/h1-5,8-11,15,29H,6-7,12-14H2,(H,23,28)(H,24,26)
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 120n/an/an/an/an/an/a



Orchid Chemicals & Pharmaceuticals Limited



Assay Description
Histone Deacetylase (HDAC) Inhibition Assay using Boc-Lys(Ac)-AMC Substrate: Inhibition of HDAC has been implicated to modulate transcription and to ...

J Enzyme Inhib Med Chem 29: 555-62 (2014)


Article DOI: 10.3109/14756366.2013.827675
BindingDB Entry DOI: 10.7270/Q22J6916
More data for this
Ligand-Target Pair