BDBM65537 (S)-4-(3-(2-((3-chlorophenyl)amino)-2-oxo-1-phenylethyl)ureido)-N-(6-(hydroxyamino)-6-oxohexyl)benzamide (L12)

SMILES: ONC(=O)CCCCCNC(=O)c1ccc(NC(=O)N[C@H](C(=O)Nc2cccc(Cl)c2)c2ccccc2)cc1

InChI Key: InChIKey=YFUNTJRMMQYHEJ-VWLOTQADSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 65537   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone deacetylase 8 (Homo sapiens (Human))	BDBM65537 ((S)-4-(3-(2-((3-chlorophenyl)amino)-2-oxo-1-phenyl...) Show SMILES ONC(=O)CCCCCNC(=O)c1ccc(NC(=O)N[C@H](C(=O)Nc2cccc(Cl)c2)c2ccccc2)cc1 Show InChI InChI=1S/C28H30ClN5O5/c29-21-10-7-11-23(18-21)31-27(37)25(19-8-3-1-4-9-19)33-28(38)32-22-15-13-20(14-16-22)26(36)30-17-6-2-5-12-24(35)34-39/h1,3-4,7-11,13-16,18,25,39H,2,5-6,12,17H2,(H,30,36)(H,31,37)(H,34,35)(H2,32,33,38)/t25-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.28E+3	n/a	n/a	n/a	n/a	n/a	n/a
Qingdao University					Assay Description The nucleus extract was extracted from HDAC8 enzyme was expressed in Escherichia coli. Boc-Lys (acetyl)-AMC was used as the substrate of HDAC. SAHA w...				J Enzyme Inhib Med Chem 29: 582-9 (2014) Article DOI: 10.3109/14756366.2013.827678 BindingDB Entry DOI: 10.7270/Q2S46Q3F
					More data for this Ligand-Target Pair