BDBM6652 3-cyclopentyl-1-(7-hydroxynaphthalen-1-yl)urea::Diarylurea deriv. 1g::N-Cyclopentyl-N -(7-hydroxy-1-naphthyl)urea
SMILES: Oc1ccc2cccc(NC(=O)NC3CCCC3)c2c1
InChI Key: InChIKey=AEHVKCHOJQHXAI-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C] (Homo sapiens (Human)) | BDBM6652 (3-cyclopentyl-1-(7-hydroxynaphthalen-1-yl)urea | D...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.50E+5 | n/a | n/a | n/a | n/a | n/a | 30 |
Banyu Tsukuba Research Institute | Assay Description In vitro kinase assays using synthetic peptides and purified enzymes were incubated at 30°C for 45 min in buffer that contained 50 uM ATP, and d... | J Med Chem 44: 4615-27 (2001) Article DOI: 10.1021/jm0103256 BindingDB Entry DOI: 10.7270/Q2736P3Q | |||||||||||
More data for this Ligand-Target Pair |